![]() ![]() Conversely, amygdala response to unmasked fearful faces was negatively correlated to the severity of affective flattening. The amygdala response to masked fearful faces was positively correlated with the degree of flat affect. With respect to masked fearful faces, no between-group differences emerged for the sample as a whole but a subsample of patients with flat affect showed heightened amygdala activation. Patients exhibited increased amygdala response to unmasked fearful faces. During scanning, a viewing task with masked and unmasked fearful and neutral faces was presented. In this study, amygdala responsivity to threat-related facial expression was investigated in patients as a function of automatic versus controlled processing and patients' flat affect.įunctional magnetic resonance imaging was used to measure amygdala activation in 36 patients with schizophrenia and 42 healthy controls. Hyperactivation was found to be related to affective flattening. Early neuroimaging studies have demonstrated amygdala hypoactivation in schizophrenia but more recent research based on paradigms with minimal cognitive loads or examining automatic processing has observed amygdala hyperactivation. ![]()
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